한국인 구강암 환자에서 인유두종 바이러스의 발현율 분석
Prevalence of Human Papillomavirus Infection in the Korean Oral Cancer Patients
김현수, 서미현, 김성민, 이종호, 명훈, 조영아, 이석근,
소속 상세정보
김현수 ( Kim Hyun-Soo ) - 서울대학교 치의학대학원 구강악안면외과학교실
서미현 ( Seo Mi-Hyun ) - 서울대학교 치의학대학원 구강악안면외과학교실
김성민 ( Kim Soung-Min ) - 서울대학교 치의학대학원 구강악안면외과학교실
이종호 ( Lee Jong-Ho ) - 서울대학교 치의학대학원 구강악안면외과학교실
명훈 ( Myoung Hoon ) - 서울대학교 치의학대학원 구강악안면외과학교실
조영아 ( Cho Yeong-Ah ) - 서울대학교 치의학대학원 구강병리학교실
이석근 ( Lee Suk-Keun ) - 강릉원주대학교 치과대학 구강병리학교실
KMID : 1036320130350040227
Abstract
Purpose: High risk human papillomavirus (HPV) is the main source of cervical cancer, nearly up to 100%. Because there are no affordable data regarding the incidence of HPV in different sites of oral cavity, the purpose of this study is to review the previous article and to find out about the incidence and types of HPV in specific areas of oral cavity.
Methods: We examined a total of 106 patients with oral cavity cancer for HPV detection. Available DNA chip (MY-HPV chip kit, Mygene Co., Korea) was used for the detection of low risk HPV types (6, 11, 34, 40, 42, 43, 44) and high risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 54, 56, 58). Patients were previously diagnosed as invasive cancer of oral cavity. Specimen used for HPV detection was extracted from the main mass during resection and were tested for HPV type, performed by a DNA chip method.
Results: Histologic results showed that there were squamous cell carcinomas, mucoepidermoid carcinomas, cystadenocarcinomas, leiomyosarcoma and etc. Among HPV positive cancer, 2 patients showed positive for high risk HPV type 16, 3 patients showed positive for low risk HPV type 6 and the other 2 patients were positive for other types of HPV. Of the 7 patients with HPV positive, 4 patients were on the tongue, 3 on the lower gingiva.
Conclusion: Most of the HPV positive cancers were on the tongue in our study. Cervical cancer of HPV infection is reported to be increasing in our society and because HPV infection largely spreads by sexual contact, the incidence of oral cancer with HPV infection is greatly assumed to be on the increase, simultaneously. Because the incidence of HPV on specific areas of oral cavity among oral cancer patients is not identified, more studies are ongoing.
키워드
Cervical cancer;DNA chip;Human papillomavirus;Oral cancer
원문 및 링크아웃 정보
등재저널 정보